![]() It was approved for medical use in the United States and in the European Union in 1998. Pfizer originally discovered the medication in 1989 while looking for a treatment for heart-related chest pain. It also results in dilation of the blood vessels in the lungs. It requires sexual arousal, however, to work. Sildenafil acts by blocking phosphodiesterase 5 (PDE 5), an enzyme that promotes breakdown of cGMP, which regulates blood flow in the penis. Sildenafil should not be taken within four hours of taking an alpha one antagonist. Sildenafil should not be taken by people on nitrates such as nitroglycerin (glycerin trinitrate), as this may result in a serious drop in blood pressure. Rare but serious side effects include a prolonged erection (priaprism) that can lead to damage to the penis, vision problems, and hearing loss. Caution is advised in those with cardiovascular disease. Ĭommon side effects include headaches, heartburn, and flushed skin. Onset is typically within 20 minutes and lasts for about 2 hours. ![]() ![]() It is taken by mouth or by injection into a vein. It is unclear if it is effective for treating sexual dysfunction in women. Sildenafil, sold under the brand name Viagra among others, is a medication used to treat erectile dysfunction and pulmonary arterial hypertension. ![]()
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